Female Genital Mutilation (FGM) is recognized internationally as a human rights violation of girls and women. It results in deep rooted inequality between the sexes and constitutes as an extreme form of discrimination against females. It violates the right to health, physical integrity, the right to be free from torture and cruelty, inhuman treatment and the right to live where it results in death. Thus, since 2003, the United Nations introduced The International Day of Zero Tolerance for Female Genital Mutilation as an annual awareness day, that is celebrated globally every 6th February as part of the UN’s efforts to eradicate Female Genital Mutilation. Female Genital Mutilation is one of the ancient cultures which has been practiced in Africa and Asia for decades. History has it that the practice of FGM came from neighboring countries such as Burkina Faso, Mali, Niger and Togo into Ghana. In Ghana, some parts of the Northern, Upper East, Upper West and Brong Ahafo and the Volta Regions including the Zongo Communities in certain urban centers of the country are notable places where the practice still goes on. It is clear that the adoption of this cultural practice of FGM has not served any good purpose in our country. Culture that violates the rights of the people is not worth practicing. The practice of FGM has serious implications on the health of the females in terms of maternal health, infant mortality self-esteem, discrimination, stigma and productivity. Indeed, the practice has no benefits for girls and women but rather in the name of ensuring fidelity in females, FGM exposes them to health hazards and psychological trauma. It causes severe bleeding, problems in urinating which can develop into cysts, infections, complications in children and increased risks of fistula during child birth. Studies show that an estimated 100 to 140 million girls and women in the world today have undergone some form of FGM and two million girls are at risk from the practice each year. Studies also indicate that in Ghana, the prevalence in the 1990s was as high as 77% but reduced drastically due to the advocacy and sensitization that has gone on. In 1994, Ghana abolished the practice of FGM and in 2011, the World Bank reported female genital mutilation prevalence as 3.8%. The current national prevalence is about 3.8% but regional prevalence, especially in the Upper East is reported to be higher. This increase could be due to the cross-border practice where people move to and fro Ghana and neighboring countries to perpetuate this crime. Nationwide surveys are being embarked on to ascertain the accurate current data per our regions. It is believed that this practice fosters our male dominant and patriarchal traditions designed to ensure fidelity and honour in women and girls. FGM is erroneously believed to be an honourable act which is a determination of womanhood. However, it does not take into consideration the fact that women and girls have a right over their sexuality. The Question is: Who checks the fidelity of the males? As the Ministry for the vulnerable, the weak, excluded and marginalized, we join the international community to condemn female genital mutilation in Ghana. As we celebrate this International Day of Zero Tolerance for FGM wewish to forge better collective responsibility with the media, faith based organizations, traditional rulers, MMDA’s, civil society and community based organizations to implement concrete actions to end FGM NOW in Ghana and to intensify public community based awareness campaigns against FGM. We have come very far as the leading African country in our practice of democracy, the rule of law and the fight for human rights. After sixty years of independence THE TIME IS NOW FOR GHANA TO STOP FGM completely. We have to understand that ending FGM is not to be narrowed down as a women’s issue or a Ministry of Gender, Children & Social Protection problem. The fight to eradicate FGM must be addressed as a national crusade that would lead to sustainable development. Ghana can no longer leave anyone out or behind, especially females. Thus, we cannot afford our women and children to be subjected to this risky, life threatening, inhuman, degrading and shameful FGM practice in this country any longer. We as a community of Ghanaians must demonstrate our commitment to protect our women and girls from human rights abuses to eliminate all forms of violence against them. The challenges are mainly attitudinal and the issues of cross border practice. The Ministry will increase collaboration with the Ministry of Health, Foreign Affairs, Interior and Regional Integration to sensitize and educate citizens from the border areas and neighbouring countries through their Embassies and or High Commissions.